3D In Vitro Disease Models, Air Pollution Toxicology, Longevity Research, Mechanobiology, Quantitative Imaging

Prof. Bibhas Roy has more than 15 years of expertise in the field of mechanobiology, aging, and rejuvenation research. His current research group focuses on how air pollutants (particularly PM2.5) induce mechanobiology-driven lung epithelium dysfunction, leading to accelerated aging and lung diseases. During his Ph.D. he worked on how oscillatory fluid shear stress induces mechanotransduction in bone cells for bone remodeling, under the supervision of Prof. Suman Chakraborty and Prof. Tapas Kumar Maiti. Prof. Roy discovered a novel approach to reprogram fibroblasts through mechanical constraints in the absence of exogenous reprogramming factors during his post-PhD research in Prof. G.V. Shivashankar’s group. Further, he established a novel cell therapy-based approach for the rejuvenation of aged fibroblasts, which was translated into aged skin rejuvenation and faster wound healing. This translational research led to many high-impact, peer-reviewed journal publications and U.S. and international patents. At Focal Biosciences AG, he headed an R&D group to develop a mechanobiology and machine learning-based high-throughput drug screening assay for lung disease.