Inventors: Abhijieet Rajendra Joshi, D Sriram and Punna Rao Ravi

This paper presents the pharmacological evaluation and characterization of a novel SARM1 inhibitor in a preclinical model of Charcot-Marie-Tooth 2A (CMT2A), a genetic neuropathy. SARM1 (Sterile Alpha and Toll/Interleukin-1 receptor motif-containing protein 1) is implicated in neuronal degeneration and axonal loss, making it a target for therapeutic intervention.