Inventors: Dr. Suman Kundu, Dr Raviprasad Aduri

Pathophysiological investigations of sickle cell disease focus on understanding its mechanisms, including hemoglobin polymerization, erythrocyte sickling, and vascular occlusion, leading to vaso-occlusive crises. Interventions aim to mitigate these abnormalities by promoting fetal haemoglobin production with therapies like hydroxyurea, enhancing oxygen delivery through transfusions, and exploring emerging gene therapies.